Setrakian, Eph, and Nora formulate a plan to track down the Master using Jim as bait. Eichhorst and Setrakian’s pasts are revealed. At the Luss home, Neeva struggles to protect the children while encountering a mysterious stranger whose help she may not want.

After warning Kelly to leave the city with Zack ahead of the spreading plague, Eph is arrested by the FBI. Eichhorst has one final job for Gus, while Setrakian realizes that the coming eclipse is the tipping point for virus infection and the beginning of the end.

With Nora gone, Eph reluctantly joins Setrakian’s quest in hopes of gathering enough evidence to warrant a citywide quarantine. Fet encounters the unexpected inside the subway tunnels, and a medical emergency threatens Palmer’s master plan.

A secret autopsy demonstrates the bizarre progression of the mystery virus, prompting Jim to make a startling confession. Eph and Nora race to find the father of the youngest victim of the plane tragedy, but someone unexpected beats them to it. Ansel, in the grip of disease, takes desperate measures to protect his family.

Eph and Nora fight to save Captain Redfern’s life before coming face-to-face with the horrifying effects of the virus. A spike in rat attacks signals Fet that something inexplicable is happening deep below the city. Released from jail, Setrakian begins his own merciless plan to stop the spread of the disease.

The four survivors begin manifesting strange symptoms, but Eph and Nora’s attempt to quarantine them is thwarted as the disinformation campaign begins. Meanwhile, in jail, Setrakian receives a surprise visit from an old – a very old – acquaintance.

When a plane lands in New York City with everyone on board dead, Dr. Ephraim Goodweather, head of the CDC’s Canary Project, and his team are called upon to investigate. Harlem pawnbroker Abraham Setrakian races to the airport, convinced that what looks at first like a mysterious viral outbreak might be the beginning of something infinitely more sinister.

Clarke and her friends must risk everything to fight one last battle for survival, only to glimpse an even darker threat to the last living valley on Earth.

Octavia leads her people into war. While behind enemy lines, our heroes must overcome their differences to save Wonkru from extinction.

As Clarke races to save Abby, she learns more about the trials and tribulations Wonkru faced in the bunker, and the impossible decisions they were forced to make in the dark year.

Monty strives to show Wonkru an alternative to war, and to the valley itself. Meanwhile, Abby’s health continues to deteriorate, along with McCreary’s patience.

The growing fractures in Wonkru threaten to explode once and for all. Meanwhile, in Shadow Valley, Murphy starts a fire, unleashing catastrophic results.

Clarke’s determination to protect Madi puts Bellamy in an impossible position.

Clarke and Bellamy make a startling discovery about Wonkru’s battle plans as Echo risks her friendship with Raven to complete her mission.

Kane’s attempt to prove himself useful tests Wonkru’s allegiance to Octavia. Madi faces an unexpected threat inside Wonkru, forcing Clarke to make an unlikely ally.

Octavia leads her people towards Shallow Valley against the advice of Clarke and Bellamy. Meanwhile, Kane and Abby adjust to a new set of challenges.

Our Heroes are forced to rely on the help of Shallow Valley’s dangerous new inhabitants in order to save some of their own, with surprising results.

Bellamy leads the charge investigating a potential way home. Meanwhile, Clarke and Madi deal with the new, uncertain threat to their home.

Octavia is forced to take guidance from an unlikely ally when the future of the bunker and all those inside it is jeopardized.

Clarke struggles to survive on a desolate, scorched earth while her friends in space come across a long-awaited beacon of hope.

It’s a race against the end of the world as Praimfaya arrives forcing our heroes to make impossible decisions to ensure their survival.

Jaha and Kane disagree over how to handle their grim reality. Meanwhile, Clarke leads a group to save a friend.

Clarke faces the consequences of her fateful choice.

Octavia fights in the final battle for her people’s survival, but not everyone is willing to play fair.

Jasper and Bellamy go on a quest. Meanwhile, Clarke struggles to keep the peace after word of Jaha’s discovery spreads.

After a disappointing discovery, Clarke and Abby question how far they’re willing to go. Meanwhile, Jaha finds a lead to the mysterious Second Dawn.

Clarke’s arrival on the island quickly takes a turn for the worse. Meanwhile, Bellamy tries to avoid further tragedy in Arkadia.

Clarke and Roan are forced to work together when they are tasked to deliver a dangerous but crucial asset to Abby through enemy territories.

Clarke makes a desperate plea with a former allied force in an attempt to avoid a war and ensure the survival of her people.

Continued struggles with leadership and trust in Arkadia and Polis take violent turns while Abby leads a team to a distant location hoping to find answers.

Jaha leads Clarke and Bellamy down a road to possible salvation while tensions rise in Arkadia and Polis.

The burden of leading weighs heavily upon Clarke and Bellamy when different challenges force them to determine who will live and die.

Clarke and her friends struggle with how to proceed after the fate of the world is revealed.

Our heroes begin to face the reality of their tragic situation. Everyone prepares for a final showdown.

Clarke finds hope in the most unlikely place. Meanwhile, Alie’s master plan comes together.