Jay has just recently married his younger, Colombian wife, Gloria, but he’s having trouble keeping up with her and her son Manny. Claire is having trouble with her own family, especially with her husband Phil, who thinks he can be hip with his three kids. Also, Mitchell and his partner Cameron adopt a Vietnamese baby, Lily.

An unexpected guest brings old conflicts to the surface, dividing the heroes and threatening the group’s trust; with questionable new intelligence in hand, the group launches a make-or-break final assault on the Master.

Reeling from loss, the heroes regroup; the heroes devise a new plan to track the Master through human collaborators, beginning at the blood farm with someone Dutch knows all too well.

With his health failing, Setrakian ignores Eph’s warnings and pushes himself to the limit in his quest for victory and revenge; Fet and Quinlan race back to Manhattan, while the Master seals off the city and prepares to eliminate them all.

Fet and Quinlan must figure out how to get the nuclear bomb back to New York, while a desperate Eichhorst draws near; love-struck Zack tries to learn more about his new crush, but makes a devastating discovery.

Fet and Quinlan track a convoy carrying their prized nuclear weapon; Eph and Alex search for clues to uncover the Master’s plan for the fate of the human race; a familiar enemy traps Dutch, who encounters an old friend as well.

Dutch is forced to make a deal with Desai, while she plots to escape a strigoi breeding facility; Eph and Alex seek to uncover the dark secrets behind the Partnership’s new plan; Gus and Creem face off against a gang encroaching on their turf.

Quinlan and Fet discover that stealing a nuclear warhead isn’t easy when they encounter an unexpected enemy. Eph and Alex concoct a new weapon to use against the strigoi. Frustrated with his seclusion, Zack discovers a love interest.

Imprisoned as a subject in a strigoi breeding program, Dutch is desperate to escape and find Setrakian. Gus recruits his cousin for the inside job that will put his gang at the top of the new world’s underground economy, but Creem is suspicious of his business partner’s ambitions.

Out of the ashes of humanity’s nuclear war, Night Eternal has begun. Haunted by the atrocities committed by his son, Eph abandons NYC for Philadelphia. His solitude is cut short when he encounters new fighters who rekindle his drive to fight back. Tasked by Setrakian, Fet and Quinlan search for a new means of stopping the Master.

Humanity teeters on the edge of destruction. The Master finally reveals himself, initiating the end game of a battle in which there can be only one winner. Eph, Fet, Setrakian, and Dutch must overcome their personal differences in a last-ditch effort to vanquish the strain.

NYC is falling. Eph and Dutch frantically race to finish their new device to stop the Master before the city is overrun. Justine, Gus, and Angel fight in one last stand to stop the spreading virus. Palmer extracts vengeance for past wrongs but may have crossed the line.

The Master’s voice proves to be more powerful and potentially fatal than Eph or Dutch anticipated. Fet and Setrakian track down the cargo from the Egyptian vessel and realize they may be in over their heads. Quinlan strikes a deal with the Ancients, but a last minute betrayal proves deadly.

Setrakian offers hope in a new plan to trap the Master while Eph and Dutch seek out the Master’s “voice.” Palmer needs Setrakian’s access to the white to hold up his end of their bargain.

Fet strikes hard at the heart of the strigoi army while Justine embarks upon a risky mission to drive the strigoi out of Manhattan once and for all. Gus and Angel fight for their lives and their freedom but are faced with a moral dilemma.

New information from the Lumen forces Setrakian to seek help from his lifelong nemesis, Eldritch Palmer. Eph’s new experiments to understand strigoi communication seemingly take him to the brink of madness while Fet is on a mission to discover strigoi movements across New York City.

Things have changed. The infection enters a new phase. Fet wants to celebrate, but Setrakian and Eph are worried there’s more work to be done. Justine conscripts a new, unwilling army in the fight while Eichhorst angrily lashes out with a plan to strike back.

The Occido Lumen is gone. Stolen. Setrakian and Fet race to recover it. Gus and Angel try to hide a secret houseguest while avoiding a police sweep, and Quinlan’s thirst for vengeance is revealed.

The Master’s offer to return Zack plagues Eph as he considers taking the deal. Dutch reunites with an old group of friends but begins to question if her safety is better with them or with Fet, Eph and Setrakian. Palmer strives for answers to Setrakian’s secret strigoi blood treatments and discovers he may have a way to acquire it.

The strigoi are evolving, becoming faster. Smarter. Eph struggles to improve his failing bioweapon while trying to work through the emotional fallout of the abduction of his son, Zack. As Setrakian and Quinlan attempt to crack the Lumen’s deepest-held secrets, Fet helps a Navy SEAL team in a deadly mission: search for the Master through the underground tunnels of New York.

Setrakian and Fet battle for possession of the Occido Lumen, and gain a surprising new ally. A massive attack imperils Eph, Nora, and Zack’s escape from New York.

Eph must choose between Zack’s safety and the safety of the citizens of NYC. Meanwhile, his relationship with Nora reaches a critical impasse, and Gus and Angel assemble an unlikely gang of Sun-hunters.

Dutch fights for her life against Eichhorst as Fet, Nora, and Eph frantically search the city for her. Setrakian confronts an old acquaintance on his search for the Occido Lumen, while Gus helps the Guptas escape across the border to safety.

Eph and Dutch work together to thwart the Master’s greatest ally. Justine runs into trouble with the Mayor while Setrakian tracks down the real owner of the Lumen.

Justine takes drastic measures to counter a surprise invasion. Nora and Fet perform a useful mission while Eph and Setrakian face off against an old foe.

Eph must protect Zack against a surprise intruder into Red Hook. Gus convinces the Guptas to make a difficult choice. Fet and Setrakian set out to acquire the Lumen.

Setrakian and Fet use Fitzwilliam’s info to attack the Master. Eph returns to NYC frustrated but energized to go after the one person responsible for killing his friends.

Eph concocts a plan to make and distribute a bioweapon. Gus realizes Angel can be an unlikely ally, and Kelly comes after Nora and Zack.

Eph changes his appearance to leave the city while Nora is left as the reluctant parent for Zack. Dutch and Nora make a deal with Justine to secure Fet’s release from jail.

Eph and Nora finally see their lethal virus in action. Fet takes the security of Red Hook into his own hands while Dutch and Setrakian set off for Staten Island to question Fitzwilliam, Palmer’s former body guard.

Gus and Vaun wage an attack on Palmer as Eph struggles to connect with Zack. Councilwoman Justine Faraldo vows to bring her extermination policies to the other boroughs.

Eph and Nora experiment on their newfound patients. Fet and Dutch grow closer as they clear out the neighborhood buildings, and Kelly begins her hunt for Zack.

Eph and Nora work on a biological weapon to kill the strigoi, and Setrakian risks the lives of the entire group to find information about a closely guarded secret text. The Master begins the next phase of his own plan, by creating a terrifying new breed of creature and placing them under the control of Kelly.

Eph and Fet recon for an all-out assault that Setrakian assures them will finally kill the Master. Gus aligns himself with a strange new force, one that may swing the fight in an unforeseen direction.

Dutch returns with a plan to broadcast Eph’s warning about the vampiric plague. However, they face a new threat when Eichhorst launches his own attack against the pawn shop. Palmer receives a special visitor, and Gus gears up for the on-coming fight but discovers there’s another mysterious factor involved.

Setrakian leads Eph, Fet and Nora in the hunt for the Master’s lair. Left behind at the pawnshop with Mariela, Zack risks his safety for Mariela’s sake.

Eph investigates Kelly’s disappearance and struggles with what he finds. Dutch pursues a plan to retaliate against Palmer, and Fitzwilliam makes a surprising choice.

Eph races to safeguard his family, only to learn that Kelly is missing. Dutch reveals her role in Palmer’s plan, and Gus is forced to make a difficult decision about Felix.

After discovering the potency of ultraviolet light against the strigoi, Setrakian gains a new and unlikely disciple. A quick trip to a Brooklyn convenience store turns into a deadly all-night siege.