By coincidence rather then by design the swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact not only on the scientific world. THE SUBSTANCE – is an investigation into our troubled relation with LSD. Told from its beginnings until today.
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In the Mexican state of Michoacán, Dr. Jose Mireles, a small-town physician known as “El Doctor,” shepherds a citizen uprising against the Knights Templar, the violent drug cartel that has wreaked havoc on the region for years. Meanwhile, in Arizona’s Altar Valley—a narrow, 52-mile-long desert corridor known as Cocaine Alley—Tim “Nailer” Foley, an American veteran, heads a small paramilitary group called Arizona Border Recon, whose goal is to halt Mexico’s drug wars from seeping across our border.
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Director Alfonso Cuarón reflects on the childhood memories, period details and creative choices that shaped his Academy Award-winning film ‘ROMA.’
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