The story follows a trio of Japanese youths of Chinese descent who escape their semi-rural upbringing and relocate to Shinjuku, Tokyo, where they befriend a troubled Shanghai prostitute and fall foul of a local crime syndicate. Like many of Miike’s works, the film examines the underbelly of respectable Japanese society and the problems of assimilation faced by non-ethnically Japanese people in Japan.
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A simple man, Dr. Walter Newman has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctor’s loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?
The destinies of two families are irrevocably tied together after a cyclist is hit off the road by a jeep in the night before Christmas Eve.
