Literature professor Jim Bennett leads a secret life as a high-stakes gambler. Always a risk-taker, Bennett bets it all when he borrows from a gangster and offers his own life as collateral. Staying one step ahead, he pits his creditor against the operator of an illicit gambling ring while garnering the attention of Frank, a paternalistic loan shark. As his relationship with a student deepens, Bennett must risk everything for a second chance.

Scientist Will Rodman is determined to find a cure for Alzheimer’s, the disease which has slowly consumed his father. Will feels certain he is close to a breakthrough and tests his latest serum on apes, noticing dramatic increases in intelligence and brain activity in the primate subjects – especially Caesar, his pet chimpanzee.

Frank Perry is an institutionalized convict twelve years into a life sentence without parole. When his estranged daughter falls ill, he is determined to make peace with her before it’s too late. He develops an ingenious escape plan, and recruits a dysfunctional band of escapists – misfits with a mutual dislike for one other but united by their desire to escape their hell hole of an existence.

Nearly a decade after occupation by an extraterrestrial force, the lives of a Chicago neighborhood on both sides of the conflict are explored.