At a 1962 College, Dean Vernon Wormer is determined to expel the entire Delta Tau Chi Fraternity, but those troublemakers have other plans for him.

Jake Blues is just out of jail, and teams up with his brother, Elwood on a ‘mission from God’ to raise funds for the orphanage in which they grew up. The only thing they can do is do what they do best – play music – so they get their old band together and they’re on their way, while getting in a bit of trouble here and there.