Set in 1970s Rome, the fiction tracks the plight of a nuclear family, consisting of an unhappy married couple: Clara (a deeply dissatisfied expatriate Spaniard) and Felice (an abusive businessman cheating on Clara with his secretary) and their children Adriana, Gino, and Diana. Their eldest child, 12-year-old Adriana, experiences gender dysphoria; he rejects girlhood and instead goes by the name of Andrea (a primarily masculine name in Italian). Andrea develops a crush for Sara, a Roma girl who knows him as a boy. Upon a shared sense of being outsiders, Andrea and Clara grow closer.

A Sicilian family deals with the arrival of a group of immigrants on their island.