The young priest Father Giulio returns to Rome, his hometown, after a long pilgrimage. Don Giulio hopes to live peacefully with his family and his friends, but discovers that many of them are depressed or frustrated, and some suicidal.

Nanni Moretti recalls in his diary three slice of life stories characterized by a sharply ironic look: in the first one he wanders through a deserted Rome, in the second he visits a reclusive friend on an island, and in the last he has to grapple with an unknown illness.