In September 2003, Alejandra López de Lemos, eldest daughter of a professor of art history at the University of Seville, disappears without a trace. All suspicions fall on her ex-husband, but the police find no evidence against him. Several months go by and the media attention wanes. Then a journalism student decides to do her final thesis on the case…

One day, Jason finds an unusual board game called Mamba. When his surfer friends start to play, the games unleashes its deadly curse, killing the losers in a gruesome fashion. Supposedly it will grant the winner a wish. As his companions die off, Jason decides that the only way he can reverse the tragedy is by continuing to play. With his girlfriend, Erica, Jason rolls the dice and hopes to make his wish before one of them suffers a horrible fate.