Siblings Gretel and Kevin are to be bestowed super powers by space aliens on their birthdays, but after Kevin’s powers accidentally go into Hamster, his pet hamster instead, they form the duo of “Hamster & Gretel”. Now Kevin must figure out how to work with both Gretel and Hamster to protect their city from mysterious dangers.

Each day, two kindhearted suburban stepbrothers on summer vacation embark on some grand new project, which annoys their controlling sister, Candace, who tries to bust them. Meanwhile, their pet platypus plots against evil Dr. Doofenshmirtz.