The evil Dr. Kochin uses the dragon balls to resurrect his mentor, Dr. Wheelo, in an effort to take over the world. Dr. Wheelo, his body having been destroyed by the avalanche that killed him fifty years before, desires the body of the strongest fighter in the world as his new vessel. Believing Roshi to be the world’s strongest warrior, Dr. Kochin abducts Bulma and forces Roshi to surrender himself to save her. When Goku hears of their abduction, he goes to their rescue.

Bison, the ruthless leader of the international terrorist organization Shadowlaw, has been desperately searching for the greatest fighter on the planet for years. He finds it in Ryu, a young wanderer who never stays in one place long enough for Bison to find him. He does, however, get a fix on Ken Masters, an American martial arts champion who studied with Ryu as a child under the same master. Meanwhile, Major Guile of the United States Army is forced to team up with Chun Li from China in hopes of apprehending Bison and putting a stop his international ring of crime.