Sue, Cheryl and Lexi are three college freshmen who have been best friends since they were born on the same day. They do something special every year for their birthday, but on their eighteenth, they set out to lose their virginity.

A group of friends get lost in the seedy streets where they encounter a crazed gang of homeless derelicts that seizes them and kills them one by one. The surviving man escapes on foot, naked and unarmed, with a pack of depraved transients in pursuit, and only seconds away from capture.