A wealthy, self-absorbed Rome socialite is tacked by guilt over the death of her young son. As a way of dealing with her grief and finding meaning in her life, she decides to devote her time and money to the city’s poor and sick. Her newfound, single-minded activism leads to conflicts with her husband and questions about her sanity.

In the South American jungle, supplies of nitroglycerine are needed at a remote oil field. The oil company pays four men to deliver the supplies in two trucks. A tense rivalry develops between the two sets of drivers on the rough remote roads where the slightest jolt can result in death.