After being stabbed in the heart by ruthless home invaders, a man is left for dead. Now weak, outnumbered, and knife sticking from his chest, he attempts to do the impossible: save his wife from these murderers before he bleeds to death.

The story follows Joe (Cage), a down-on-his-luck truck driver haunted by the memory of his deceased wife and child. He meets Julie (Potente), a spiritually gifted woman who enlists Joe in a desperate effort to find the lost soul of her comatose daughter, Billie (Mitchell). But the spirit of Joe’s dead wife Mary proves stronger, possessing the young woman’s body and determined to settle her unfinished business with the living.