In Tokyo, a young woman is exposed to the same mysterious curse that afflicted her sister. The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.

Freed of her responsibilities with the 501 Organization, Motoko Kusanagi must now learn how to take orders from Aramaki. Someone hacks the Logicomas, and Batou enlists the help of former army intelligence officer Ishikawa and former air artillery expert Borma. Kusanagi also seeks to enlist ace sniper Saito and undercover cop Paz into the new Public Security Section 9.

While driving, the pregnant horror-movie actress Kyôko Harase and her fiancé are in a car crash caused by the Toshio’s friend. Kyôko loses her baby and her fiancé winds up in a coma. Kyôko was cursed together with a television crew when they shot a show in the haunted house where Kayako was brutally murdered by her husband years ago.