After spending two decades in England, Bill Bryson returns to the U.S., where he decides the best way to connect with his homeland is to hike the Appalachian Trail with one of his oldest friends.

Lonnie, a crop duster pilot, must lead a mismatched group of survivors to escape the deadly zombie horde after an experimental chemical, intended to control the invasive kudzu vine, transforms the citizens of Charleston, MS into zombies.