The down-and-out private detective Harry Angel is ordered, by a mysterious man named Louis Cyphre, to go on a mission to find a missing person. His routine failure soon leads to a bloody spar with himself as Harry Angel goes on a supernatural journey into his own soul.

New Orleans businessman Michael Courtland’s life is shattered when his wife and daughter are tragically killed in a botched kidnap rescue attempt. Many years later whilst visiting Italy he meets and falls in in love with Sandra Portinari, who bears a striking resemblance to his wife.