A killer known as Ghostface begins killing off teenagers, and as the body count begins rising, one girl and her friends find themselves contemplating the ‘rules’ of horror films as they find themselves living in a real-life one.

Sidney Prescott, now the author of a self-help book, returns home to Woodsboro on the last stop of her book tour. There she reconnects with Sheriff Dewey and Gale, who are now married, as well as her cousin Jill and her Aunt Kate. Unfortunately, Sidney’s appearance also brings about the return of Ghostface, putting Sidney, Gale, and Dewey, along with Jill, her friends, and the whole town of Woodsboro in danger.

A murdering spree begins to happen again, this time its targeted toward the original Woodsboro survivors and those associated with the movie inside a movie, ‘Stab 3’. Sydney must face the demons of her past to stop the killer.

Two years after the terrifying events that occurred in Woodsboro, Sidney is now attending Windsor College in Cincinnati, and Gale Weathers’ best selling book on Sidney’s life has now been made into a major motion picture. When two college students are killed in a theatre while watching the new film ‘Stab’, Sidney knows deep down that history is repeating itself.

The Powerpuff Girls Movie tells the origin story of how the Powerpuff Girls were created and how they came to be the defenders of Townsville. It was the first Hanna-Barbera/Cartoon Network Studios theatrical feature film since 1993’s Once Upon a Forest, and is the only film based on a Cartoon Network series to be released theatrically.