A pair of truck drivers happen onto a decrepit roadside fast food stop selling ramen noodles. The widowed owner, Tampopo, pleads them to help her turn her establishment into a paragon of the “art of noodle soup making”.

The Toxic Avenger is lured to Tokyo, Japan by the evil corporation Apocalypse Inc. So while the Toxic Avenger is fighting crime in Tokyo, Apocalypse Inc. spread evil in Tromaville.