Jeff Bailey seems to be a mundane gas station owner in remote Bridgeport, CA. He is dating local girl Ann Miller and lives a quiet life. But Jeff has a secret past, and when a mysterious stranger arrives in town, Jeff is forced to return to the dark world he had tried to escape.
When Dr. Anthony Edwardes arrives at a Vermont mental hospital to replace the outgoing hospital director, Dr. Constance Peterson, a psychoanalyst, discovers Edwardes is actually an impostor. The man confesses that the real Dr. Edwardes is dead and fears he may have killed him, but cannot recall anything. Dr. Peterson, however is convinced his impostor is innocent of the man’s murder, and joins him on a quest to unravel his amnesia through psychoanalysis.
In 1916, beautiful young mute Helen is a domestic worker for elderly, ailing Mrs. Warren. Mrs. Warren’s two adult sons, Albert (a professor) and womanizing impudent Steven, also live in the Warren mansion. Mrs. Warren becomes concerned for Helen’s safety when a rash of murders involving ‘women with afflictions’ hits the neighborhood. She implores her physician, Dr. Parry, to take Helen away for her own safety. When another murder occurs inside the Warren mansion, it becomes obvious that Helen is in danger.
Buffalo Bill and Wild Bill Hickok join forces to establish a mail route that can get mail from St. Joseph, Missouri, to Sacramento, California, in ten days. Along the way they must battle bad weather, hostile Indians and outlaws intent on robbing the mail and shutting down the entire operation.