A scientist at a Florida university inadvertently creates a “rage virus” while performing experiments intended to restore dead brain tissue in baboons. When a journalist for the college paper breaks into the campus lab, he’s bitten by one of the infected baboons; the virus soon spreads to a trio of rapists and a valley girl, all of whom go on killing sprees.

Courtney, the sister of a survivor from the 1st movie and the members of her rock band go to a condo for the weekend to play music and have fun with their boyfriends. Courtney’s dreams are of her sister, who is in a mental institution, warning her of having sex, and the dreams begin to spill into real life, threatening Courtney and her friends as they begin experiencing an attrition problem.