While doing undercover work in a mental hospital, Emanuelle discovers a girl who seems to have been raised by a tribe of amazonian cannibals. Intrigued, Emanuelle and friends travel deep into the Amazon jungle, where they find that the supposedly extinct tribe of cannibals is still very much alive.

A bickering couple driving cross-country pick up a murderous hitchhiker whom threatens to kill them unless they take him to a santuary, and in return agrees to split some bank loot he has on him.