If your enemy refuses to be humbled… Destroy him. Accompanied by his brother Kurt (Van Damme), American kickboxing champion Eric Sloane (Dennis Alexio), arrives in Thailand to defeat the Eastern warriors at their own sport. His opponent: ruthless fighter and Thai champion, Tong Po. Tong not only defeats Eric, he paralyzes him for life. Crazed with anger, Kurt vows revenge.

Lyon Gaultier is a deserter in the Foreign Legion arriving in the USA entirely hard up. He finds his brother between life and death and his sister-in-law without the money needed to heal her husband and to maintain her child. To earn the money needed, Gaultier decides to take part in some very dangerous clandestine fights.

In this rousing sequel to Kickboxer, Tong Po broods about his defeat at the hands of Kurt Sloan. Po and his managers resort to drastic measures to goad Kurt into the ring for a rematch.