Buenos Aires screenwriter Pablo is hired to write a new romantic comedy. As he begins his story, he visualizes his characters living in Madrid. Pablo creates a meet-cute between Marina and Víctor, a cute couple in Madrid who are soon totally in love. Yet as Pablo gets more and more into the script, he finds it difficult to separate his movie characters from what is happening in his own real life – specifically, his own love life.

A young priest travels to Buenos Aires in order to help sick people during the 1871 yellow fever epidemic.