A shady police detective becomes embroiled in a strange world of murder, sadism and madness after being assigned a murder investigation against a madman known only as “The Engineer”.

A fanatical animal rights activist (Debbie Gibson) releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger (Tiffany) feeds experimental steroids to wild alligators so they can fight back. The giant pythons and gargantuan alligators go on a killing spree, and it is now left up to the two feuding women to put aside their differences to put a stop to the creatures and the destruction.

A deadly collision between a train and car lead to an unlikely bond between the train engineer and a young boy who escapes the carnage.