Former CIA spy Bob Ho takes on his toughest assignment to date: looking after his girlfriend’s three kids, who haven’t exactly warmed to their mom’s beau. And when one of the youngsters accidentally downloads a top-secret formula, Bob’s longtime nemesis, a Russian terrorist, pays a visit to the family.

An odd-but-gifted poet, Evan Merck (Wes Bentley, ‘American Beauty’) makes his living writing suicide notes for the soon-to-be departed. So when he meets Charlotte (Winona Ryder, ‘Girl, Interrupted’), the free-spirited sister of his latest client, Evan has no choice but to lie about his relationship to her late, lamented brother.

In Jacksonville, Florida, four friends since grade school who are now in their early 30s face the challenges of adulthood: Hutto is about to become a father, Laith is intimidated by his girlfriend’s sexuality, a grieving Bobby drinks heavily and sleeps on the grave of a girlfriend who’s been dead 18 months, and Mark, an OB/GYN who loves his work, can’t practice medicine because he can’t afford malpractice insurance. Things come to a head when Mark needs his three friends’ help after a belligerent animal-abusing pornographer attacks Mark with a gun over something Laith did. A midnight road trip tests friendship: can the guys help each other?