In the late 1890s the Davenport House was a famous and successful brothel, until a young prostitute named Alice killed herself there. After her death, the brothel became haunted by Alice’s ghost, and was eventually abandoned. More than a century later, the old structure is renovated into a beautiful mansion. It is still rumored to inhabit the ghost of Alice. Despite this, the new owner; the rich and arrogant heir to the Davenport fortune, decides to throw a wild party for his first night in the house.
Amy has moved east from Kansas, determined to start a new life. She thinks she has found the perfect small quiet town, a great neighborhood on a quiet street. As she moves into her brand new apartment, eager to start a dream job, happy to befriend her neighbors, she finds out that not everything is as it seems, especially at the house across the street.
In 1957, insurance investigator George Lazarus is tasked with interviewing twelve employees of the Deadly Sin Cigarette Company when his firm receives a suspicious insurance claim. He learns that all twelve had been let go after contracting mysterious illnesses, but before he can report back, Lazarus goes missing without a trace. After his disappearance, his fiancée Bethany and his friend Chip set out to find him – but what they uncover may actually signal the end of the entire human race.