At a remote Arctic research station, four ecology students discover the real horror of global warming is not the melting ice, but what’s frozen within it. A prehistoric parasite is released from the carcass of a Woolly Mammoth upon the unsuspecting students who are forced to quarantine and make necessary sacrifices, or risk infecting the rest of the world.

Ace assassin Frank Kitchen is double crossed by gangsters and falls into the hands of rogue surgeon known as The Doctor who turns him into a woman. The hitman, now a hitwoman, sets out for revenge, aided by a nurse named Johnnie who also has secrets.