In 1989, a breakthrough in “advanced parasitic research” on Cuttyhunk Island gave scientists a jump in human evolution. Initial tests proved promising, as subjects experienced heightened physical and mental strength and awareness. But – something in the experiment went horribly wrong, and the island mysteriously lost three quarters of its population.

A gunslinger, a vengeful ex-slave, and a runaway board a midnight train to Atlanta. They discover that the train is haunted by a sinister force, and must fight to survive the night.