Return to the Class of Nuke ‘Em High follows a young couple that are up against the school glee club. Unfortunately, the glee club has mutated into a gang called The Cretins. When the other students begin to undergo mutations, our couple must solve the mystery and save Tromaville High School

Years after a violent attack sent her into retirement, opera soprano Sarah Conrad has agreed to a comeback event. But when she steps back into the limelight, a series of new dangers threaten to keep her from ever singing again.