Flight attendant Cassandra Bowden wakes in her hotel room hungover from the night before in Dubai with a dead body lying next to her. Afraid to call the police, she continues her morning as if nothing happened. In New York, she is met by FBI agents who question her about her recent layover in Dubai. Still unable to piece the night together, she begins to wonder if she could be the killer.

When an internet company decides to investigate a series of ‘Screamer’ videos, they are confronted with havoc and hell they could never expect.