Dave Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade’s gang is racing to free him.

In order to flee from powerful enemies, young Mayan king Balam leads his people north across the Gulf of Mexico to the coast of what will become the United States. They build a home in the new land but come into conflict with a tribe of Native Americans led by their chief, Black Eagle, while both Balam and Black Eagle fall in love the beautiful Mayan princess Ixchel.

Sam Burton’s second wife Neddy is Indian, their son Pacer a half-breed. As struggle starts between the whites and the Kiowas, the Burton family is split between loyalties.