Some time after the Mousekewitz’s have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan.

A young mouse named Fievel and his family decide to migrate to America, a “land without cats,” at the turn of the 20th century. But somehow, Fievel ends up in the New World alone and must fend off not only the felines he never thought he’d have to deal with again but also the loneliness of being away from home.

When Manny Singer’s wife dies, his young daughter Molly becomes mute and withdrawn. To help cope with looking after Molly, he hires sassy housekeeper Corrina Washington, who coaxes Molly out of her shell and shows father and daughter a whole new way of life. Manny and Corrina’s friendship delights Molly and enrages the other townspeople.

Fievel and his friend Tony Toponi find a map that they believe points to a treasure buried somewhere beneath Old New York, and the plucky rodent is determined to find it. However, what he discovers under the city is a tribe of Native American mice who were driven underground by prejudiced European immigrants.

Story of the relationships between two sons and their father, who moves the family to California and becomes a tv horror show host after the death of his wife.