In 1979, a delivery truck makes its way up a lonely southern California highway in a storm, bound for the San Diego Zoo with a deadly tropical rattlesnake as cargo. When the truck suffers a blowout, the driver loses control and hits a tree, shattering the snake’s aquarium in the back and the window separating the snake from the driver. The snake slithers into the front of the truck, kills the driver with its bite and then moves off into the forest. Flash forward to 1999. The small southern California town of San Vicente has grown from 6,000 to 30,000, and the rattler, which escaped nearby years ago, has bred. There are now 25,000 of these hybrid rattlesnakes, and they are slowly making their way downhill into the town, attracted by the movement of the blasting as the town paves its way toward progress. Progress, in this case, brings terror, in this tale originally penned by John Carpenter.

Geeky student Arnie Cunningham falls for Christine, a rusty 1958 Plymouth Fury, and becomes obsessed with restoring the classic automobile to her former glory. As the car changes, so does Arnie, whose newfound confidence turns to arrogance behind the wheel of his exotic beauty. Arnie’s girlfriend Leigh and best friend Dennis reach out to him, only to be met by a Fury like no other.

Middle-aged widow Beatrice Hunsdorfer (Joanne Woodward) and her daughters Ruth (Roberta Wallach) and Matilda (Nell Potts) are struggling to survive in a society they barely understand. Beatrice dreams of opening an elegant tea room but does not have the wherewithal to achieve her lofty goal. Epileptic Ruth is a rebellious adolescent, while shy but highly intelligent and idealistic Matilda seeks solace in her pets and school projects, including one designed to show how small amounts of radium affect marigolds.