Captain Etienne Navarre is a man on whose shoulders lies a cruel curse. Punished for loving each other, Navarre must become a wolf by night whilst his lover, Lady Isabeau, takes the form of a hawk by day. Together, with the thief Philippe Gaston, they must try to overthrow the corrupt Bishop and in doing so break the spell.

A man has been driven insane by church-sanctioned scientific experimentation which also causes him to be nearly impossible to kill. He is pursued to America by a priest where he embarks upon a killing spree while the priest tries to hunt him down and kill him.