After his cattle rancher boss dies, right-hand man Pike is given the job of returning $86,000 to some families who live across the border in Senora, Mexico. Honest Pike is joined on the trip through the wilderness by a dishonest gambler named Tyree

Roberto, a shy law student in Rome, meets Bruno, a forty-year-old exuberant, capricious man, who takes him for a drive through the Roman and Tuscany countries in the summer.

A reporter and a blind retired journalist try to solve a series of murders. The crimes are connected to experiments by a pharmaceutical company in secret research. The two end up becoming targets of the killer.