Caleb, a former government assassin in hiding, who resurfaces when his protégé, the equally deadly killer known as Banshee, discovers a bounty has been placed on Caleb’s head.

Lt. Wakes is a vengeful police detective determined to solve the murders of his partner and an informant, and joins forces with a witness injured during the shootings. After the killers pursue the witness across the abandoned floor of a hospital, she confirms Wakes’s worst fears.