A pack of werewolves known as the Hell Hounds wage a shadow war against a fanatical order of werewolf hunters called the Silver Bullets. The Hounds and the Bullets now roam the country appearing to the outside world as rival biker gangs.

After looting a Native American burial site, a hunter unleashes the legendary Skinwalker, a shape shifting demon, onto an unsuspecting world.

A trail of revenge leads a notorious killer and a lawman to a town of fanatics.