Ten years after the first American Pie movie, three new hapless virgins discover the Bible hidden in the school library at East Great Falls High. Unfortunately for them, the book is ruined, and with incomplete advice, the Bible leads them on a hilarious journey to lose their virginity.

A young athlete takes a wild turn in life after suffering a serious injury.

Uncle Frankie (Danny Trejo) is not the kind of guy you want to meet in a dark alley. Especially when you owe him money and have been giving him the slip for a few years. Such is the fate of Lorenzo Adams (Gary Moore), a top bill collector at Lump Sum Collections. Uncle Frankie has tracked Lorenzo to Norfolk, Virginia and is coming to collect.

A young campaign aide gets in way over his head when he sleeps with the wife of a presidential candidate, sending him into a downward spiral of corruption and blackmail. He is left fighting not only for his career, but also his life.