After a series of murders occur, two vampire hunters and some FBI agents hunt down the empress vampire who caused the mayhem.

Vinny and Sebastion, two burnouts, going nowhere in small town suburbia and still riding the high of their high-school days, start a business doing the only thing they have ever excelled at…drugs. With the help of a jealous girlfriend and a rich goth chick, Vinny and Sebastion take on the mob, angry, geeky, frat-boys, and zombies in the search of the perfect high.