Carl Lucas / Frankenstein has won four of his races and needs to win one more to win his freedom. Before his final race, Lucas and his team, car and all, are transferred to another prison where they will compete in a Death Race in the desert. Also, at the same time, Ceaser runs into a marketer who wants to franchise the Death Race program.

Six strangers find themselves in circumstances beyond their control, and must use their wits to survive.