Mildred Moyer transforms from shy misfit to loveable psychopath when her back-alley plastic surgery is botched. Mildred finds herself living her best life as she unleashes brutal vengeance on all those who tormented her in the past.

A psychiatric hospital is turned upside down when a mysterious drifter is admitted and assigned to room 316. Known only as John Doe, the other patients believe that he bears an uncanny resemblance to Jesus Christ.