Awkward telemarketer Martha Plant is down and out — sucking at her job and grieving her recently deceased parents. When she finds unlikely friendship in Sadie Mayflower, a bubbly vagrant with multiple personalities, Martha discovers having three friends in one may be more than she bargained for.

Ship engineer Jim Taggert is rescued from a torpedoed tramp steamer by Joe Morgan, an American gangster that found New York too hot for him, and has become a fisherman operating from an out-of-the-way island off of the coast of South America. Morgan makes his headquarters at the Halfway House run by the parents of Maria Styx as a bar and dance resort catering to the planters and traders of the island. Taggert finds himself practically a prisoner along with a group of American girls acting as entertainers at the resort. Taggert shadows Morgan in his activities in a remote cove and finds that Morgan is supplying German U-boat commanders with torpedoes, but does not know that Morgan has rigged the torpedoes with clock devices that explode when at sea and sinks the U-boats.

Shiftless Jeeter Lester and his family of sharecroppers live in rural Georgia where their ancestors were once wealthy planters. Their slapstick existence is threatened by a bank’s plans to take over the land for more profitable farming.