An attractive and successful doctor places a personal ad in a newspaper to try to meet (and eventually marry) Mr. Right. A succession of blind dates ensues, featuring men who are lonely, desperate, dangerous and perverted.

Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline “Desperately Seeking Susan” proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan’s life.