Tod Lubitch is born with a deficient immune system. As such, he must spend the rest of his life in a completely sterile environment. His room is completely hermetically sealed against bacteria and virus, his food is specially prepared, and his only human contact comes in the form of gloved hands. The movie follows his life into a teenager.

Jimmy is young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom… who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy — bubble suit and all — treks cross-country to stop her. Swoosie Kurtz, as Jimmy’s overprotective mom, co-stars along with Fabio, who portrays the leader of a religious cult.