The Templeton brothers — Tim and his Boss Baby little bro Ted — have become adults and drifted away from each other. But a new boss baby with a cutting-edge approach and a can-do attitude is about to bring them together again … and inspire a new family business.

25-year-old philosophy major Marta faces the ugly truth for many young Italians — a complete lack of career opportunities. While babysitting for single mother Sonia, she starts to work as a telemarketer, experiencing first-hand the fanatical and exploitative rat-race culture pushed on employees while quickly rising through the ranks of the company. Around her revolve people like delusional supervisor Daniela, her womanizing boss Claudio, fragile coworker Lucio “2”, and well-meaning but inconsistent union rep Giorgio.

A drug sniffing agent canine is a target for an assassin boss so the FBI calls Witness Protection to send him somewhere else. Meanwhile a single Mom puts her 6 year old boy James in the care of her irresponsible, mailman, neighbor, Gordon, when the babysitter bails on her. Meanwhile, an assassin mob boss hires 2 goons to kill Agent 11. But when 11 escapes from the van when they tried to kill him, he hides in Gordon’s Mailtruck that James is in too. And guess what they name him. Spot.