Seven masked bandits, whose chief calls himself “Mormon”, kidnap young Susy, cousin of the mayor of Clayton City, Frank Clonny. Frank accepts the $15,000 ransom requested by the bandits and thinks of a plan which will permit him, with the help of Benson, the sheriff, to free his cousin, recover the money and capture the outlaws. The plan, though, is destined to fail, because one of the mayor’s men, Donovan, allows the bandits to escape the trap. Benson then decides to call in Sartana, who the Mormon immediately tries to eliminate with the help of four killers: Buffalo, who kills with a bullwhip; Martinez, an expert knife thrower; Sullivan, a giant of incredible strength and Silky, a sly and fast gunslinger.

After a flight back home, Sam Hendrix returns with a doll he innocently acquired along the way. As it turns out, the doll is actually stuffed with heroin, and a group of criminals led by the ruthless Roat has followed Hendrix back to his place to retrieve it. When Hendrix leaves for business, the crooks make their move — and find his blind wife, Susy, alone in the apartment. Soon, a life-threatening game begins between Susy and the thugs.