Hélène Masson visits her friend Gérôme Savignat in the isolated rejuvenation clinic owned by Dr. Devilers and his partner Dr. Berbard. But after a series of tragic events, Hélène goes further in her investigation of the clinic.

Suddenly left without his trusted caretaker, Ptolemy Grey is assigned to the care of orphaned teenager Robyn. When they learn about a treatment that will restore Ptolemy’s dementia-addled memories, it begins a journey toward shocking truths.

After suffering the recent loss of his wife, David Reynolds decides to take his family on a cathartic trip to her home village in Columbia. While en route, they get into a car accident and seek refuge in a secluded inn. While there they find a mysterious young girl, Ana Maria, locked up with cryptic symbols painted on the walls of her cell. Shocked by the treatment of her caretaker, the family sets Ana free only to realize that she is possessed by an evil spirit from centuries past. What’s worse, the spirit can jump from person to person, creating a deadly dynamic amongst the once loving family. Now, David must figure out a way to lock the spirit up for good before it destroys him and his family.

After being released from prison, Dr. Nise da Silveira is back at work in a psychiatric hospital on the outskirts of Rio de Janeirom where she refuses to employ the new and violent electroshock in the treatment of schizophrenics. Ridiculed by doctors, she is forced to take on the abandoned Sector for Occupational Therapy, where she would start a revolution through paintings, animals and love.

In October 2009, the filmmakers went into an abandoned psychiatric hospital to explore the ‘haunted’ institution, famous for its radical treatment of patients with mental illness. Electroshock, insulin therapy, and lobotomies were commonplace. Once inside, the filmmakers quickly discovered that they were not alone.