Baltimore. New Year’s Eve. A talented but troubled police officer is recruited by the FBI’s chief investigator to help profile and track down a mass murderer.

Ainsley (Kelsey Gunn) is a misanthrope who hates people but when she suddenly finds herself in isolation with no one to talk to, she realizes how much she actually misses connection. Enter Ulysses, a dead mouse in a jar. With a little bit of loneliness, a pinch of imagination, and a mouse-sized tuxedo, Ulysses becomes her training wheels in this newly discovered world of friendship.

Self-described misanthrope Elle Reid has her protective bubble burst when her 18-year-old granddaughter, Sage, shows up needing help. The two of them go on a day-long journey that causes Elle to come to terms with her past and Sage to confront her future.

Serge Tanneur (Fabrice Luchini) is at the pinnacle of his acting career when he decides to turn his back on show business and become a hermit living off of France’s Atlantic coast. Three years later, Gauthier Valence (Lambert Wilson), a beloved TV actor, shows up on the island to offer Serge a role in his directorial debut – a rendition of Molière’s classic play, “The Misanthrope”. Serge refuses at first, but then suggests that they rehearse the first scene and after five days he’ll decide if he wants to dothe play or not. What ensues is a battle of brawn and wits and peculiar encounters with a hotel maid who longs to be a pornstar and an Italian divorcée.

A former war vet, a misanthrope, and an illegal immigrant seek salvation in a pair of inexperienced drug dealers staked out at a run-down desert motel.

When Michael McCann is thrown over by the woman he loves, he becomes something of a misanthrope and a miser, spending all of his spare money on collectible gold coins. Living in the same town is an affluent family with two sons: John and Tanny. Tanny’s a wild boy, whom John cannot control, and one night he breaks into McCann’s house, and steals the gold and disappears, which nearly confirms McCann’s distrust of mankind. But then, a mysterious young woman dies in the snow outside McCann’s house, and her small daughter makes her way to McCann’s house and into McCann’s life and heart. He names her Matilda, and raises her, finding companionship and a new joy in life with his adopted daughter. But the secret of Matilda’s birth may tear them apart.

Curmudgeon. Contrarian. Misanthrope. Naysayer. For all the people interviewed in this film, someone has used one of the above words to describe them. What have they done to deserve such labels? Everywhere these men and women go, something is being celebrated; they don’t get what all the celebration is about and they’re compelled to question it.