Two unsuspecting actresses are hired for what they believe to be a Murder Mystery Weekend on a secluded island, only to learn that the murders are all too real! Each of the unwary victims has been lured to the island so that an unknown killer can eliminate them one by one until one helpless victim finds herself literally nailed to the wall! Who is the killer and who are his victims?

Ghosts of Mississippi is a drama covering the final trial of the assassin, Bryon De La Beckwith, of the 60s civil rights leader Medgar Evers. It begins with the murder and the events surrounding the two initial trials which both ended in a hung jury. The movie then covers District Attorney, Bobby DeLaughters transformation and alliance with Myrlie Evers, wife of Medgar Evers, of the, as he becomes more involved with bringing Beckwith to trial for the third time 30 years later. Some of the characters are played by the actual participants in this story.